![]() “In my 15 years of experience as a breast cancer clinician, I’ve never seen such a marked improvement in efficacy with a new drug compared to the current standard therapy for metastatic breast cancer, so it really is quite exciting for our patients,” Dr. The superior response to T-DXd was “very impressive” and suggests that this drug should be the new standard second-line treatment for such patients, said Alexandra Zimmer, M.D., clinical director of the Women’s Malignancies Branch in NCI’s Center for Cancer Research, who was not involved with the study. Twelve months after treatment started, the cancer was still under control in nearly 76% of people in the trastuzumab deruxtecan, or T-DXd group, compared with 34% of those treated with T-DM1, said senior study investigator Sara Hurvitz, M.D., of the UCLA Jonsson Comprehensive Cancer Center. Although the trial is ongoing, a planned interim analysis of data from the study showed a clear difference between the two treatments. Interim results of the clinical trial, which compared the two drugs in people whose disease had progressed after treatment with at least one earlier regimen for metastatic breast cancer, were presented September 18 at the European Society for Medical Oncology (ESMO) Congress 2021. Since 2013, trastuzumab emtansine, commonly abbreviated as T-DM1, has been the preferred second-line treatment for people with metastatic breast cancer that overproduces the HER2 protein, known as HER2-positive breast cancer. In a head-to-head comparison, trastuzumab deruxtecan (Enhertu) was also better at shrinking tumors than another targeted drug, trastuzumab emtansine (Kadcyla). The approval was based on the results of the DESTINY-Breast03 trial, details of which are discussed in the story below.Ī new targeted drug markedly lengthened the time that people with an aggressive subtype of metastatic breast cancer lived without their cancer progressing, new study results show. ![]() if they received the HER2-targeted therapy before or after surgery for early-stage breast cancer and their cancer returned during, or within 6 months of completing, that treatment.if their cancer has spread (metastatic) or cannot be treated with surgery.Under the approval, the drug can be used in such adults UPDATE: On May 4, 2022, the Food and Drug Administration (FDA) expanded the approval of trastuzumab deruxtecan (Enhertu) for the treatment of some adults with HER2-positive breast cancer who have previously received a HER2-targeted therapy. ![]()
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